Our methodological developments are accompanied by software implementations.

These software implementations in SAS and R and interactive webtools allow wide application of our methods.

• Statistical software – Implementations of analysis methods in SAS and R

• webtools – interactive sample size calculation, estimation of percentiles and risk calculators

For completeness we describe two external software packages for biometrical planning of studies and randomization:

• nQuery – software for flexible estimation of sample sizes for planned studies

• Randomizer – web-based randomization of therapy assignment for mono- and multicenter studies